In aesthetics, innovation never stands still. While injectables like fillers and skin boosters remain popular, the new era of regenerative medicine is taking centre stage. One of the most advanced treatments now available is Polynucleotides, a scientifically backed therapy that goes beyond hydration or wrinkle reduction to repair and regenerate the skin at a cellular level.
At The Medispa, with clinics in Telford, Shrewsbury, Wolverhampton, and Walsall, we are proud to be among the first in the UK to offer this groundbreaking treatment. Our medical team is dedicated to bringing the latest global advancements to our clients, ensuring natural, safe, and clinically proven results.
What Exactly Are Polynucleotides?
Polynucleotides are purified DNA fragments derived from natural sources, carefully processed for use in aesthetic medicine. Unlike traditional injectables, which focus on adding volume or relaxing muscles, Polynucleotides work with your body to repair and rejuvenate the skin from within.
They act as biostimulators, encouraging your skin’s fibroblasts (the cells responsible for collagen and elastin production) to regenerate. This means the improvements go far deeper than the surface—helping your skin function and appear as if it were younger, healthier, and more resilient.
The Science Behind Polynucleotides
The effectiveness of polynucleotides lies in their ability to:
- Stimulate Fibroblasts
Fibroblasts are key to skin health. As we age, their activity slows, leading to thinner, looser, and drier skin. Polynucleotides reactivate these cells, kick-starting natural collagen and elastin production. - Enhance Tissue Repair
Polynucleotides accelerate wound healing, making them ideal for treating scars, stretch marks, and damaged skin. - Hydrate at a Cellular Level
By binding to water molecules, polynucleotides improve hydration within the dermis, leaving skin plumper and more supple. - Neutralise Free Radicals
Acting as antioxidants, they protect skin cells from oxidative stress caused by pollution, UV rays, and lifestyle factors. - Support Angiogenesis
They encourage the formation of new blood vessels, improving circulation and nutrient delivery to the skin.
The result? A healthier, firmer, smoother, and more radiant complexion.
Key Benefits of Polynucleotide Treatments
Clients choose polynucleotides at The Medispa because they offer visible improvements that remain natural-looking. Benefits include:
- Noticeable improvement in skin quality and density
- Reduced fine lines and wrinkles
- Firmer, more elastic skin with better “bounce”
- Brighter, fresher, and more radiant complexion
- Hydrated skin with long-lasting results
- Reduction in dark circles and under-eye hollows
- Improved healing of scars and damaged tissue
- Enhanced results when combined with Profhilo, fillers, or skin tightening
Where Can Polynucleotides Be Used?
One of the advantages of polynucleotides is their versatility. At The Medispa, we successfully treat:
- Face – overall rejuvenation, texture improvement, and fine lines
- Under Eyes – tackling dark circles, hollowness, and tired-looking skin
- Neck & Décolletage – reducing crepiness and sagging skin
- Hands – restoring softness and youthful skin quality
- Scarring & Stretch Marks – aiding regeneration and healing
This makes polynucleotides ideal for both targeted problem areas and full-face skin restoration.
Polynucleotides vs Other Skin Boosters
With the growing number of injectable treatments, clients often want clarity on what makes polynucleotides unique. Here’s how they compare:
- Dermal Fillers – Best for restoring lost volume and reshaping features.
- Profhilo – Works as an injectable moisturiser, providing hydration and mild tightening.
- Polynucleotides – Focused on true regeneration, repairing damage, stimulating fibroblasts, and restoring long-term skin health.
For many women, the best results come from a combination treatment plan, which our expert practitioners will design specifically for your needs.
The Treatment Experience at The Medispa
When you choose The Medispa for polynucleotides, your journey is designed to be comfortable, safe, and results-driven.
- Comprehensive Consultation
During your first visit, one of our experienced practitioners will examine your skin, discuss your goals, and determine if polynucleotides are right for you. - Personalised Treatment Plan
Depending on your concerns, we may recommend a full-face course or targeted injections (for example, under the eyes). - The Procedure
Treatment takes around 30–45 minutes. A series of precise micro-injections deliver the polynucleotides into the chosen areas. Discomfort is minimal and numbing cream can be applied if required. - Recovery
Downtime is very limited. You may notice mild redness, swelling, or tiny bumps at the injection site, which settle within 24–48 hours. - Results
Improvements are gradual and natural-looking, with results continuing to improve over several weeks as collagen stimulation takes effect.
How Many Treatments Will I Need?
For most clients, we recommend a course of 3 treatments spaced 3–4 weeks apart. Maintenance sessions every 6–12 months will prolong results.
This structured approach ensures your skin receives the cumulative benefits of polynucleotides, maximising long-term rejuvenation.
Safety and Side Effects
Safety is paramount at The Medispa. Polynucleotides are biocompatible and well-tolerated, making them suitable for most skin types.
Potential side effects include:
- Mild redness or swelling
- Temporary tenderness
- Small bumps at the injection site
All of these resolve quickly and are considered part of the normal healing process.
Who Is Suitable for Polynucleotide Treatment?
Polynucleotides are ideal for:
- Women aged 30+ noticing early or advanced signs of ageing
- Those struggling with loss of elasticity and firmness
- Clients seeking natural improvements rather than dramatic changes
- Individuals with tired, dull, or dehydrated skin
- Those wanting to improve under-eye hollows or pigmentation
- People looking for skin regeneration after sun damage or scarring
Why Choose The Medispa?
At The Medispa, we combine medical expertise, cutting-edge treatments, and a commitment to natural results. Our clients trust us because:
- Treatments are carried out by experienced aesthetic practitioners and medical staff
- We are among the first in the UK to offer polynucleotides
- Every treatment plan is fully bespoke
- Our reputation for discretion and excellence makes us one of the most trusted aesthetics clinics in the region
With clinics in Telford, Shrewsbury, Wolverhampton, and Walsall, we bring premium regenerative treatments to your local area.
Frequently Asked Questions (Advanced)
Are Polynucleotides safe for sensitive skin?
Yes. They are hypoallergenic and highly biocompatible, making them suitable even for sensitive skin.
How do Polynucleotides compare to PRP (Platelet Rich Plasma)?
While PRP facials use your own platelets for regeneration, polynucleotides are specifically engineered for consistent, targeted skin repair and hydration.
Will Polynucleotides change my facial features?
No. Unlike fillers, they do not add volume. Instead, they improve the quality of your existing skin for a naturally refreshed look.
Can Polynucleotides be combined with other treatments?
Yes. Many clients combine them with Profhilo, fillers, anti-wrinkle injections, or skin tightening for enhanced results.
When will I see results?
Initial improvements in hydration may be noticeable within days, while collagen regeneration continues to develop over 4–6 weeks.
Book Your Polynucleotides Consultation
Polynucleotides represent the future of regenerative aesthetics—a science-led treatment that restores skin from the inside out. If you want healthier, firmer, and more radiant skin without altering your natural look, this treatment is an excellent choice.
At The Medispa, we combine expert medical care with the latest in global aesthetic innovation. With clinics in Telford, Shrewsbury, Wolverhampton, and Walsall, your journey to radiant skin is closer than you think.
✨ Book your consultation today and discover the natural power of Polynucleotides at The Medispa.
